Figure 5

A network of miRNAs, their target genes, and potential interacting partners associated with aging. miRNAs that change expression upon aging of virgin flies are shown in the inner circle in yellow boxes and are connected to their target genes, shown in the middle circle, with red lines. The miRNA target genes are connected with known interaction partners, shown in the outer circle, with grey lines. Genes that are targets for H3K4me1, H3K4me3 and H3K9ac, are shown in orange, green and red boxes, respectively. Myb is a target for both H3K4me3 and H3K9ac, as indicated by the red border around the green box. Note that only miRNAs and target genes that undergo altered transcriptional regulation are included in the network, and only genes interacting with more than one miRNA target are represented in the outer circle.