Figure 1

ROC curves performance of EASE and EASE-AA using two different evaluation schemes. The true positive rate of EASE and EASE-AA is shown as a function of the false positive rate at different prediction thresholds. These are independent test results using the unseen-mutation and unseen-protein evaluation. While for EASE-AA the area under the ROC curve (AUC) declined only by 0.02 when comparing the unseen-mutation and unseen-protein evaluation, EASE yielded a decrease of 0.11.