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Table 4 Real-value prediction performance of the four methods optimised for the unseen-protein evaluation

From: Towards sequence-based prediction of mutation-induced stability changes in unseen non-homologous proteins

Method

Evaluation

r

RMSE

SEQ-NEIGHB

 

0.35

1.67

SEQ-FREQ

unseen-protein

0.36

1.67

EASE

cross-validation

0.42

1.62

EASE-AA

 

0.51

1.54

SEQ-NEIGHB

 

0.34

1.61

SEQ-FREQ

unseen-protein

0.36

1.60

EASE

independent test

0.41

1.56

EASE-AA

 

0.51

1.48