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Table 3 Rank correlations (ρ) and partial rank correlations (ρp) of the examined genomic properties with expression dissimilarities (measured by ExpD1-r or ExpDEuc) of the adjacent paralogous genes of different orientations.

From: Accumulation of CTCF-binding sites drives expression divergence between tandemly duplicated genes in humans

Genomic properties a

ExpD 1-r

ExpD Euc

 

ρ (P-value) b

ρp (P-value) b,c

ρ (P-value) b

ρp (P-value) b,c

Head-to-Head d

   d

0.165 (0.072)

0.106 (0.250)

0.150 (0.109)

0.036 (0.700)

   #CTCF

0.213 (0.020)

0.173 (0.058)

0.352 (<10-4)

0.327 (<10-3)

   ΔCpGO/E

-0.024 (0.794)

0.001 (0.991)

-0.071 (0.443)

-0.054 (0.561)

Head-to-Tail d

   d

0.005 (0.870)

-0.050 (0.110)

0.089 (<10-2)

0.016 (0.607)

   #CTCF

0.100 (<10-2)

0.110 (<10-3)

0.151 (<10-5)

0.127 (<10-4)

   ΔCpGO/E

0.083 (<10-2)

0.085 (<10-2)

0.109 (<10-3)

0.104 (<10-3)

Tail-to-Tail d

   d

0.139 (0.110)

0.105 (0.230)

0.145 (0.096)

0.046 (0.602)

   #CTCF

0.113 (0.195)

0.061 (0.482)

0.271 (<10-2)

0.202 (0.019)

   ΔCpGO/E

0.050 (0.569)

0.018 (0.0835)

0.212 (0.014)

0.153 (0.078)

  1. a "d", intergenic distance; "#CTCF", number of overlapping CTCF-binding sites; "ΔCpGO/E", difference in upstream DNA methylation.
  2. b P values show the probabilities of the observations under the hypothesis of no correlation.
  3. c Spearman's partial correlation coefficient ρp is computed by controlling for the other two genomic properties listed in a
  4. d There were 120, 1003 and 133 head-to-head, head-to-tail and tail-to-tail adjacent paralogs, respectively.