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Table 4 Rank correlations (ρ) and partial rank correlations (ρp) of the examined genomic properties with the divergence time of the paralogous adjacent genes.

From: Accumulation of CTCF-binding sites drives expression divergence between tandemly duplicated genes in humans

Genomic properties a

d S

T phy

 

ρ (P-value) b

ρp (P-value) b,c

ρ (P-value) b

ρp (P-value) b,c

All adjacent paralogs

   d

0.138 (<10-5)

0.057 (0.056)

0.141 (<10-6)

0.053 (0.060)

   #CTCF

0.225 (<10-13)

0.189 (<10-9)

0.219 (<10-14)

0.178 (<10-9)

   ΔCpGO/E

0.097 (<10-2)

0.089 (<10-2)

0.084 (<10-2)

0.073 (<10-2)

Adjacent paralogs associated with GO terms in which high #CTCF/d genes were specifically enriched

   d

0.086 (0.152)

-0.070 (0.245)

0.108 (0.072)

-0.038 (0.526)

   #CTCF

0.292 (<10-6)

0.276 (<10-5)

0.273 (<10-5)

0.243 (<10-4)

   ΔCpGO/E

0.122 (0.043)

0.079 (0.186)

0.132 (0.027)

0.092 (0.125)

  1. a "d", intergenic distance; "#CTCF", number of overlapping CTCF-binding sites; "ΔCpGO/E", difference in upstream DNA methylation.
  2. b P values show the probabilities of the observations under the hypothesis of no correlation.
  3. c Spearman's partial correlation coefficient ρp is computed by controlling for the other two genomic properties listed in a