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Table 5 Enriched/depleted GO terms at level 4 for genes with high #CTCF/d flanking regions

From: Accumulation of CTCF-binding sites drives expression divergence between tandemly duplicated genes in humans

Functional categories

Duplicate with 25% top #CTCF/dvs. rest of duplicates

Non-duplicates with 25% top #CTCF/dvs. rest of non-duplicates

 

GO terms a (↑ or ↓b, P-value c)

GO terms (↑ or ↓b, P-value c)

Molecular functions

 

DNA binding

(GO:0003677) (↑, P<0.05)

transferase activity, transferring phosphorus-containing groups

(GO:0016772) (↑, P<10-7)

 

transcription factor binding

(GO:0008134) (↑, P<10-2)

hydrolase activity, acting on acid anhydrides (GO:0016817) (↑, P<10-4)

 

SMAD binding

(GO:0046332) (↑, P<0.05)

protein domain specific binding

(GO:0019904) (↑, P<10-2)

 

growth factor binding

(GO:0019838) (↑, P<0.05)

substrate-specific transmembrane transporter activity (GO:0022891) (↑, P<10-4)

 

kinase inhibitor activity

(GO:0019210) (↑, P<0.05)

cytoskeletal protein binding

(GO:0008092) (↑, P<10-7)

 

peptidase inhibitor activity

(GO:0030414) (↑, P<0.05)

phospholipid binding

(GO:0005543) (↑, P<10-2)

 

protein kinase regulator activity

(GO:0019887) (↑, P<0.05)

identical protein binding

(GO:0042802) (↑, P<10-8)

 

transferase activity, transferring acyl groups (GO:0016746) (↑, P<0.05)

receptor binding

(GO:0005102) (↑, P<10-9)

 

transferase activity, transferring glycosyl groups (GO:0016757) (↓, P<0.05)

heat shock protein binding

(GO:0031072) (↑, P<0.05)

 

monooxygenase activity

(GO:0004497) (↓, P<0.05)

oxidoreductase activity, acting on peroxide as acceptor (GO:0016684) (↑, P<10-2)

Cellular components

 

extracellular matrix

(GO:0031012) (↑, P<10-6)

extracellular matrix

(GO:0031012) (↑, P<10-3)

 

intracellular

(GO:0031012) (↑, P<0.05)

extracelluar space

(GO:0005615) (↑, P<10-8)

 

receptor complex (GO:0043235) (↑, P<0.05)

endomembrane system

(GO:0012505) (↑, P<10-3)

  

membrane-bounded vesicle (GO:0031988) (↑, P<0.05)

  

cell surface

(GO:0009986) (↑, P<10-4)

  

cell projection

(GO:0042995) (↑, P<0.05)

  

midbody

(GO:0030496) (↑, P<0.05)

Biological processes

 

response to organic substance

(GO:0010033) (↑, P<0.05)

response to organic substance

(GO:0010033) (↑, P<10-5)

 

regulation of metabolic process

(GO:0019222) (↑, P<10-3)

lipid metabolic process

(GO:0006629) (↑, P<10-6)

 

regulation of catalytic activity

(GO:0050790) (↑, P<10-2)

defense response

(GO:0006952) (↑, P<10-3)

 

regulation of cellular process

(GO:0050794) (↑, P<10-3)

response to other organism

(GO:0051707) (↑, P<0.05)

 

regulation of cellular component organization (GO:0051128) (↑, P<0.05)

carbohydrate metabolic process

(GO:0005975) (↑, P<0.05)

 

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

(GO:0006139) (↑, P<10-2)

response to drug

(GO:0042493) (↑, P<10-3)

 

macromolecule biosynthetic process (GO:0009059) (↑, P<10-3)

cell-cell signaling

(GO:0007267) (↑, P<10-2)

 

gene expression

(GO:0010467) (↑, P<10-2)

cytoskeleton organization

(GO:0007010) (↑, P<10-3)

 

cellular biosynthetic process

(GO:0044249) (↑, P<10-4)

regulation of developmental process (GO:0050793) (↑, P<10-4)

 

programmed cell death

(GO:0012501) (↑, P<10-2)

regulation of immune system process (GO:0002682) (↑, P<10-4)

  1. a Specifically enriched GO terms are highlighted in bold fonts
  2. b The symbol ↑or ↓ represents the enrichment status of "enriched" or "depleted" of the GO term, respectively.
  3. c P values were Bonferroni-corrected for multiple tests