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Figure 2 | BMC Genomics

Figure 2

From: Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers

Figure 2

Morphological characterization of lung tumors from K-rasLA1/p53R172HΔg mice. A-G: Hematoxylin-eosin evaluation of lung sections from a WT transgenic mouse (A), one representative 10- (B), 20- (C) and 30- (D-G) week-old K-rasLA1/p53R172HΔg mice (A-D magnification ×200; E-G magnification ×400). A: normal lung tissue; B: initial lesions with aspects of lepidic growth; C: subpleural lesion with papillary and solid patterns; D: adenocarcinoma nodule with solid pattern of growth; E: tumor zone with a solid growth pattern composed of cohesive cell agglomerates in a nest-like configuration without acinar polarity; F: tumor zone with papillary growth. Papillae show fibrovascular cores lined by cells with large vesicular nuclei containing very prominent nucleoli; G: poorly differentiated tumor zone with highly polymorphic cells and cells with aberrant nuclei. H: Immunohistochemical staining for TTF-1 lung tumor lesions from one representative 30-week-old K-rasLA1/p53R172HΔg mouse (magnification ×100).

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