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Table 1 The distribution of COSMIC "missense" and "coding silent" mutations mapped onto the target structures in IL-10 centered network.

From: The structural network of Interleukin-10 and its implications in inflammation and cancer

Protein

PDB

Mutation Number

Protein

PDB

Mutation Number

A2M

2p9rA

16

IL10

2ilkA

12

A2M

1bv8A

7

IL10RA

1lqsR

25

A2M

4acqC

139

IL10RB

3lqmA

24

ADAMTS1

2jihB

34

IL1B

3ltqA

16

AMBP

4es7A

12

IL28B

3hhcB

21

ANXA6

1m9iA

35

IL4

1bbnA

9

APOE

2kc3A

5

KLK3

2zchP

29

APOE

2l7bA

8

LEP

1ax8A

11

APP

1tknA

13

LRP1

2knyA

7

APP

3ktmE

9

LYZ

1lz6A

6

APP

2llmA

5

MMP2

3ayuA

20

APP

3nylA

21

NGF

1wwwW

10

APP

1owtA

6

PDGFA

3mjkA

6

APP

3umkA

20

SHBG

1kdkA

6

B2M

1ypzB

22

SIRPG

2jjwA

12

B2M

3ov6A

29

TGFBI

1x3bA

15

BTRC

1p22A

30

TP63

2y9tA

8

CPB2

3d68A

33

TP63

2rmnA

29

CTSB

3pbhA

22

TP63

4a9zC

5

ERBB4

2ahxB

121

UBC

3b0aD

21