Table 4 Classification performance measurements from three tools (%).
From: In silico comparative characterization of pharmacogenomic missense variants
Classification | Sensitivity | Specificity | Accuracy | Precision | F-Measure | AUC |
|---|---|---|---|---|---|---|
SIFT | Â | Â | Â | Â | Â | Â |
Disease/neutral | 71.1 | 71.1 | 71.1 | 75.1 | 73.1 | 77.3 |
   PGx/disease | 71.1 | 60.6 | 65.8 | 90.3 | 79.6 | 70.5 |
   PGx/neutral |  |  |  |  |  | 54.8 |
PolyPhen2 | Â | Â | Â | Â | Â | Â |
Disease/neutral | 85.3 | 57.1 | 71.2 | 72.7 | 78.5 | 76.9 |
   PGx/disease | 85.3 | 54.0 | 69.6 | 90.6 | 87.8 | 69.9 |
   PGx/neutral |  |  |  |  |  | 53.8 |
MutPred | Â | Â | Â | Â | Â | Â |
Disease/neutral | 98.5 | 76.6 | 87.5 | 84.9 | 91.2 | 95.1 |
   PGx/disease | 98.5 | 61.1 | 79.8 | 92.9 | 95.6 | 85.9 |
   PGx/neutral |  |  |  |  |  | 59.1 |