GWAS and drug targets

BMC Genomics

Table 3 dN/dS analysis for GWAS reported genes and drug targets

		Number of genes	Mean dN/dS	P Value for Mann-Whitney test against all genes	P Value for Mann-Whitney test against GWAS reported genes
Human-Mouse orthologs	All genes	13691	0.22
	GWAS reported genes	2932	0.19	2.44e^-09*
	Drug targets	1035	0.18	1.21e^-04*	0.43
	Drug targets with known mechanism	432	0.17	6.04e^-06*	0.038*
	HGMD genes	720	0.20	1.0
Human-Chimpanzee orthologs	All genes	14173	0.44
	GWAS reported genes	2911	0.36	1.26e^-13*
	Drug targets	1020	0.33	2.78e^-13*	0.0098*
	Drug targets with known mechanism	423	0.32	4.20e^-08*	0.013*
	HGMD genes	699	0.36	0.002*

ISSN: 1471-2164