Computational identification of multi-omic correlates of anticancer therapeutic response

BMC Genomics

Table 1 Common drugs in the Cancer Genome Project (CGP) and Cancer Cell Line Encyclopedia (CCLE) datasets

Compound	Target(s)	Class	Organization
17-AAG*	HSP90	Targeted other	Bristol-Myers Squibb
AZD0530	Src, Abl, EGFR	Kinase Inhibitor	AstraZeneca
AZD6244*	MEK	Kinase Inhibitor	AstraZeneca
Crizotinib*	c-MET, ALK	Kinase Inhibitor	Pfizer
Erlotinib*	EGFR	Kinase Inhibitor	Genentech
Lapatinib*	EGFR, HER2	Kinase Inhibitor	GlaxoSmithKline
Nilotinib*	Abl/Bcr-Abl	Kinase Inhibitor	Novartis
Nutlin-3*	MDM2	Targeted other	Roche
NVP-TAE684*	ALK	Kinase Inhibitor	Novartis
Paclitaxel*	Beta-Tubulin	Cytotoxic	Bristol-Myers Squibb
PD-0325901	MEK	Kinase Inhibitor	Pfizer
PD-0332991	CDK4/6	Kinase Inhibitor	Pfizer
PHA-665752	c-MET	Kinase Inhibitor	Pfizer
PLX4720	RAF	Kinase Inhibitor	Plexxikon
Sorafenib*	FLT3, c-KIT, PDGFR, RET, Raf kinases, VEGFR, KDR, FLT4	Kinase Inhibitor	Bayer

ISSN: 1471-2164