Skip to main content

Table 1 Brief molecular description of the model components.

From: Modelling the onset of senescence at the G1/S cell cycle checkpoint

Node

Description

SSB

Single strand break: 0 (no break), (1) reparable and (2) irreparable SSB

DSB

Double strand break: 0 (no break), (1) reparable and (2) irreparable DSB

ATR

Ataxia telangiectasia and Rad3 related protein

ATM

Ataxia telangiectasia mutated protein

CHEK2

Checkpoint kinase 2 protein

CHEK1

Checkpoint kinase 1 protein

p14ARF

Alternate reading frame (ARF) protein (from CDKN2A locus)

p16INK4a

Cyclin-dependent kinase inhibitor 2A protein (from CDKN2A locus)

p38MAPK

Mitogen activated protein kinase 14 protein

Mdm2

E3 ubiquitin protein ligase homolog protein

p21

Cyclin-dependent kinase inhibitor 1A protein

p53

Tumor supressor protein p53 protein

CDC25A

Cell division cycle 25A protein

E2F

E2F transcription factor family of proteins (E2F1, E2F2, E2F3)

RB1

Retinoblastoma 1 protein

CDK46CycD

Protein complex: Cyclin-dependent kinase 4, 6 and Cyclin D

CDK2CycE

Protein complex: Cyclin-dependent kinase 2 and Cyclin E