From: Modelling the onset of senescence at the G1/S cell cycle checkpoint
Node | Description |
---|---|
SSB | Single strand break: 0 (no break), (1) reparable and (2) irreparable SSB |
DSB | Double strand break: 0 (no break), (1) reparable and (2) irreparable DSB |
ATR | Ataxia telangiectasia and Rad3 related protein |
ATM | Ataxia telangiectasia mutated protein |
CHEK2 | Checkpoint kinase 2 protein |
CHEK1 | Checkpoint kinase 1 protein |
p14ARF | Alternate reading frame (ARF) protein (from CDKN2A locus) |
p16INK4a | Cyclin-dependent kinase inhibitor 2A protein (from CDKN2A locus) |
p38MAPK | Mitogen activated protein kinase 14 protein |
Mdm2 | E3 ubiquitin protein ligase homolog protein |
p21 | Cyclin-dependent kinase inhibitor 1A protein |
p53 | Tumor supressor protein p53 protein |
CDC25A | Cell division cycle 25A protein |
E2F | E2F transcription factor family of proteins (E2F1, E2F2, E2F3) |
RB1 | Retinoblastoma 1 protein |
CDK46CycD | Protein complex: Cyclin-dependent kinase 4, 6 and Cyclin D |
CDK2CycE | Protein complex: Cyclin-dependent kinase 2 and Cyclin E |