Table 1 Canonical pathways predicted by Ingenuity Pathway Analysis.

Glycerolipid Metabolism

6.85E+00

1.36E-01

SDC1 (includes EG:20969),DGAT2,ADH1C (includes EG:11522),LIPE,GK,PNPLA2,ADH1A,GPAM,PPAPDC1A,PPAPDC1B,AADAC,ALDH2,ALDH1A1,PPAP2A,ALDH1A3,AGPAT2,ALDH1A2,LPL,ADH1B,MGLL,PPAP2C

Mitotic Roles of Polo-Like Kinase

5.26E+00

2.15E-01

KIF23,CDC25C,CDC20,PTTG1,PRC1 (includes EG:233406),CDC7 (includes EG:12545),CCNB2,PLK1,CDK1,CCNB1,PLK4,ANAPC5,PPP2R1B,KIF11

Cardiac β-adrenergic Signaling

4.95E+00

1.36E-01

AKAP12,PDE2A,PLN,PPP1R1A,ADRBK2,ATP2A3,PPP1R14A,PDE1A,PDE1C,AKAP2/PALM2-AKAP2,PRKAR2B,GNG11,PDE7B,PDE3B,PDE1B,MRAS,PDE8B,GNG2,PPP1CA,PPP2R1B,APEX1

ATM Signaling

4.70E+00

2.22E-01

RAD51,CDC25C,SMC2,FANCD2,MAPK10,CCNB2,CREB3L4,MAPK13,CREB5,CDK1,CHEK1,CCNB1

ILK Signaling

4.50E+00

1.30E-01

FN1,MYH11,CREB5,RHOH,KRT18,RHOU,FIGF,AKT3 (includes EG:10000),ACTG2,MUC1,CFL1,FERMT2,PIK3C2G,RHOJ,CREB3L4,MYL9,RHOQ,RND3,FLNC,CFL2,ARHGEF6,MAPK10,LEF1,PPP2R1B,MMP9

Protein Kinase A Signaling

3.93E+00

1.03E-01

AKAP12,PHKG2,LIPE,PDE1A,CREB5,HIST2H3C (includes others),PTCH2,TGFBR2,GNG11,PDE7B,PDE3B,PPP1CA,HIST1H1B,APEX1,PDE2A,PLN,GNAI1,PPP1R14A,PYGL,CREB3L4,TTN (includes EG:22138),PDE1C,MYL9,AKAP2/PALM2-AKAP2,PRKAR2B,PYGM,ADD3,FLNC,PDE1B,ANAPC5,PDE8B,LEF1,GNG2,TCF7L2

Leukocyte Extravasation Signaling

3.43E+00

1.15E-01

VAV2,RAC2,CLDN11,JAM2,PIK3C2G,GNAI1,MMP13,MAPK13,CLDN7,DLC1,ITGAL,RHOH,TIMP4,CLDN4,CLDN8,EZR,CXCL12 (includes EG:20315),MAPK10,PECAM1,MMP11,ACTG2,MMP9,CLDN3

Atherosclerosis Signaling

3.11E+00

1.22E-01

CMA1,CD36,MMP13,PLA2G2A,F3,APOC1,IL33,PLA2G4A,ALB,CXCL12 (includes EG:20315),LPL,COL10A1,PDGFD,MMP9,APOD,RBP4

Glycolysis/Gluconeogenesis

2.98E+00

9.85E-02

PGK1,ADH1C (includes EG:11522), ALDH1L1, ALDH2, HK1,ADH1A ,ALDH1A1,ALDH1A3,ALDH1A2,PGM5,ADH1B, ACSL1,ALDOC

Agrin Interactions at Neuromuscular Junction

2.93E+00

1.59E-01

RAC2,PAK3,ARHGEF6,LAMA2,MRAS,MAPK10,ERBB3,ACTG2,ERBB2,ITGAL,EGFR

IL-8 Signaling

2.84E+00

1.04E-01

RAC2,ANGPT1,PIK3C2G,GNAI1,RHOJ,IRAK3,RHOH,CDH1,RHOQ,GNG11,RND3,MAPK10,RHOU,MRAS,AKT3 (includes EG:10000),FIGF,GNG2,MMP9,ITGAX,EGFR

Inhibition of Angiogenesis by TSP1

2.65E+00

1.79E-01

TGFBR2,SDC1 (includes EG:20969),MAPK10,CD36,AKT3 (includes EG:10000),MAPK13,MMP9

Interferon Signaling

2.65E+00

1.94E-01

OAS1,MX1,IRF9,STAT1,TAP1,BAK1,IRF1 (includes EG:16362)

Cell Cycle: G2/M DNA Damage Checkpoint Regulation

2.60E+00

1.63E-01

CDC25C,CKS2,TOP2A,CCNB2,PLK1,CDK1,CHEK1,CCNB1

Cell Cycle Control of Chromosomal Replication

2.52E+00

1.94E-01

MCM3,CDC45,CDC6 (includes EG:23834),CDC7 (includes EG:12545),MCM4,MCM7

Role of BRCA1 in DNA Damage Response

2.47E+00

1.48E-01

RAD51,FANCD2,E2F5,BRCA2,PLK1,BRIP1,STAT1,BLM,CHEK1

Integrin Signaling

2.47E+00

1.00E-01

RAC2,CAPN6,TSPAN7,PIK3C2G,RHOJ,ITGAL,TTN (includes EG:22138), RHOH,MYL9,RHOQ, TLN2,PAK3, RND3,TSPAN1,CAV1,MRAS,RHOU,AKT3 (includes EG:10000), ACTG2 ,ITGA7, ITGAX

RhoGDI Signaling

2.39E+00

9.45E-02

CFL1,GNAI1,RHOJ,DLC1,RHOH,MYL9,CDH2,CDH1,RHOQ,GNG11,PAK3,RND3,EZR,CFL2,ARHGEF6,MRAS,RHOU,ACTG2,GNG2

Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

2.34E+00

9.05E-02

PIK3C2G,PPP1R14A,RHOJ,MAPK13,RHOH,IRF1 (includes EG:16362), APOC1, ALB,RHOQ, RND3,CAT,RHOU,MAPK10,AKT3 (includes EG:10000),STAT1,PPP1CA,PPP2R1B,APOD,RBP4

Hereditary Breast Cancer Signaling

2.29E+00

1.09E-01

CDC25C,HDAC1,PIK3C2G,CDK1,CHEK1,CCNB1,RAD51,FANCD2,MRAS,AKT3 (includes EG:10000),POLR2H,BRCA2,BLM,UBC

Bile Acid Biosynthesis

2.04E+00

7.55E-02

ALDH2,ADH1A,AKR1C1/AKR1C2,ALDH1A1,ALDH1A3,ALDH1A2,ADH1C (includes EG:11522),ADH1B

Estrogen-Dependent Breast Cancer Signaling

1.77E+00

1.14E-01

HSD17B13,IGF1,MRAS,PIK3C2G,AKT3 (includes EG:10000),CREB3L4,CREB5,EGFR

HER-2 Signaling in Breast Cancer

1.21E+00

9.88E-02

CCNE2,MRAS,PIK3C2G,PARD6B,AKT3 (includes EG:10000),ERBB3,ERBB2,EGFR

Breast Cancer Regulation by Stathmin1

7.29E-01

6.67E-02

CCNE2,GNAI1,PIK3C2G,PPP1R14A,CDK1,GNG11,PRKAR2B,ARHGEF6,E2F5,MRAS,TUBA1C,GNG2,PPP1CA,PPP2R1B