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Table 2 Characteristics of INCENP variants detected in this study.

From: Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis

Cell line

Genomic positions

Nucleotide change

Amino acid change

Type

Evolutionary conservation

SIFT analysis*

1CT7

q12.3

c. T1517>C

p. M506T

Single AA change

Yes

0.03

1CT7

q12.3

c.G1931>C

p. E644D

Single AA change

Yes

0.101

1CT7

q12.3

c. T1187>C

p.N396N

Synonymous

No

0.894

  1. * Prediction of a change to be deleterious (<0.05) or tolerated.
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BMC Genomics

ISSN: 1471-2164

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