Figure 3From: Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profilingUPmiRs regulatory network. This network involves 536 interactions between 33 UPmiRs and 204 DEGs. Fifteen of the 48 UPmiRs did not have known validated targets (Table 2). The regulator hub-UPmiR is miR-381-3p which has 45 target genes (Table S3.1). Down-regulated Nfib being targeted by 12 UPmiRs (Table S3.2) is the miRNA target hub. The background of hub-miRNAs/genes is marked in purple. The V-shaped nodes correspond to the miRNAs, while the rectangle-shaped nodes are the target genes. The up-regulated miRNAs/genes are marked in red; down-regulated miRNAs/genes are marked in green. Regulatory effects are illustrated as blunt ends (⊥) between miRNAs and genes.Back to article page