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Table 4 The top 20 pathways assigned to AIDS-related lncRNA HCP5 by our LncRNA2Function.

From: LncRNA2Function: a comprehensive resource for functional investigation of human lncRNAs based on RNA-seq data

Pahtway

database

Pahtway name

Background frequency

Sample frequency

P-value

Corrected P-value

Reactome

Immune System

1177/20447

98/458

1.66E-30

2.14E-27

KEGG

Natural killer cell mediated cytotoxicity

219/20447

38/458

6.00E-23

3.87E-20

PID

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

104/20447

28/458

1.06E-22

4.54E-20

Reactome

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

202/20447

35/458

3.36E-21

1.08E-18

Reactome

Adaptive Immune System

772/20447

66/458

4.68E-21

1.21E-18

NetPath

TCR

252/20447

36/458

6.84E-19

1.47E-16

KEGG

Chemokine signaling pathway

195/20447

30/458

7.56E-17

1.39E-14

PID

Generation of second messenger molecules

15/20447

11/458

7.96E-16

1.28E-13

KEGG

Osteoclast differentiation

174/20447

27/458

2.20E-15

3.16E-13

PID

TCR signaling in naive CD4+ T cells

80/20447

19/458

1.03E-14

1.32E-12

PID

TCR signaling in naive CD8+ T cells

63/20447

17/458

2.63E-14

3.09E-12

PID

IL12-mediated signaling events

81/20447

18/458

1.80E-13

1.94E-11

KEGG

Cytokine-cytokine receptor interaction

291/20447

31/458

6.97E-13

6.42E-11

Reactome

Innate Immune System

542/20447

43/458

6.96E-13

6.42E-11

KEGG

Hematopoietic cell lineage

114/20447

20/458

9.26E-13

7.97E-11

KEGG

T cell receptor signaling pathway

116/20447

20/458

1.30E-12

1.05E-10

Reactome

Cell surface interactions at the vascular wall

104/20447

19/458

1.62E-12

1.23E-10

PID

Cell surface interactions at the vascular wall

42/20447

13/458

4.26E-12

3.06E-10

Reactome

Class A/1 (Rhodopsin-like receptors)

319/20447

31/458

7.85E-12

5.33E-10

PID

Fc-epsilon receptor I signaling in mast cells

64/20447

15/458

8.34E-12

5.38E-10