GO Term | No. of genes | Bonferroni adjusted P-value | Total No. of optimal ceRNA pairs/ceRNAs | GBM corea | OV corea | LUSC corea | LAML corea | CV among cancersb |
---|---|---|---|---|---|---|---|---|
Cluster 1 (Enrichment Score: 17.99) | ||||||||
GO:0046907~intracellular transport | 184 | 9.26E-18 | Â | Â | Â | Â | Â | Â |
GO:0008104~protein localization | 225 | 7.88E-17 | Â | Â | Â | Â | Â | Â |
GO:0015031~protein transport | 200 | 4.67E-16 | Â | Â | Â | Â | Â | Â |
GO:0045184~establishment of protein localization | 201 | 6.18E-16 | 8229/261 | 7152/261 | 6235/258 | 3961/254 | 2755/247 | 34.85%/2.06% |
GO:0070727~cellular macromolecule localization | 126 | 2.75E-14 | Â | Â | Â | Â | Â | Â |
GO:0034613~cellular protein localization | 124 | 1.09E-13 | Â | Â | Â | Â | Â | Â |
GO:0006886~intracellular protein transport | 111 | 3.17E-11 | Â | Â | Â | Â | Â | Â |
Cluster 2 (Enrichment Score: 8.27) | ||||||||
GO:0009057~macromolecule catabolic process | 180 | 2.95E-08 | Â | Â | Â | Â | Â | Â |
GO:0044265~cellular macromolecule catabolic process | 168 | 1.04E-07 | Â | Â | Â | Â | Â | Â |
GO:0030163~protein catabolic process | 143 | 6.75E-06 | Â | Â | Â | Â | Â | Â |
GO:0043632~modification-dependent macromolecule catabolic process | 134 | 8.41E-06 | Â | Â | Â | Â | Â | Â |
GO:0019941~modification-dependent protein catabolic process | 134 | 8.41E-06 | 4838/200 | 4418/200 | 3836/197 | 2379/193 | 2049/191 | 31.08%/1.79% |
GO:0051603~proteolysis involved in cellular protein catabolic process | 138 | 1.31E-05 | Â | Â | Â | Â | Â | Â |
GO:0044257~cellular protein catabolic process | 138 | 1.85E-05 | Â | Â | Â | Â | Â | Â |
GO:0006511~ubiquitin-dependent protein catabolic process | 68 | 8.96E-05 | Â | Â | Â | Â | Â | Â |
GO:0006508~proteolysis | 177 | 1 | Â | Â | Â | Â | Â | Â |
Cluster 3 (Enrichment Score: 6.01) | ||||||||
GO:0016192~vesicle-mediated transport | 141 | 8.98E-08 | Â | Â | Â | Â | Â | Â |
GO:0016044~membraneorganization | 93 | 3.70E-04 | 3462/157 | 2882/155 | 2519/156 | 1607/149 | 1208/147 | 32.82%/2.53% |
GO:0010324~membrane invagination | 50 | 0.935246 | Â | Â | Â | Â | Â | Â |
GO:0006897~endocytosis | 50 | 0.935246 | Â | Â | Â | Â | Â | Â |
Cluster 4 (Enrichment Score: 5.67) | ||||||||
GO:0032446~protein modification by small protein conjugation | 45 | 6.85E-05 | Â | Â | Â | Â | Â | Â |
GO:0070647~protein modification by small protein conjugation or removal | 50 | 2.36E-04 | Â | Â | Â | Â | Â | Â |
GO:0016567~protein ubiquitination | 40 | 7.30E-04 | Â | Â | Â | Â | Â | Â |
GO:0019787~small conjugating protein ligase activity | 45 | 0.012039 | 607/67 | 555/67 | 488/66 | 335/65 | 266/62 | 28.13%/2.88% |
GO:0016881~acid-amino acid ligase activity | 51 | 0.020482 | Â | Â | Â | Â | Â | Â |
GO:0004842~ubiquitin-protein ligase activity | 39 | 0.084550 | Â | Â | Â | Â | Â | Â |
GO:0016879~ligase activity, forming carbon-nitrogen bonds | 53 | 0.213866 | Â | Â | Â | Â | Â | Â |
Cluster 5 (Enrichment Score: 5.10) | ||||||||
GO:0010608~posttranscription al regulation of gene expression | 59 | 0.001017 | Â | Â | Â | Â | Â | Â |
GO:0006417~regulation of translation | 40 | 0.036298 | 1312/105 | 1132/105 | 961/101 | 643/99 | 480/100 | 31.90%/2.25% |
GO:0032268~regulation of cellular protein metabolic process | 96 | 0.576893 | Â | Â | Â | Â | Â | Â |