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Figure 3 | BMC Genomics

Figure 3

From: Detection of gene annotations and protein-protein interaction associated disorders through transitive relationships between integrated annotations

Figure 3

GPKB Web interface: Search result page. The transferred new annotation of the Insulin-like growth factor 2 (somatomedin A) (IGF2) human gene to the Insulin-like growth factor binding biological function is shown. (Notice the external links on all IDs, the "Show new transitive relationships only" button and the "Download" icon.) As all annotations in the GPKB that are transferred by the transitive relationship method, it is clearly marked with the value "TRANSITIVE_RELATIONSHIP" of its Inferred attribute. By clicking on the icon next to it (see the arrow), the "Transitive relationship full provenance" window pops up and shows all the available known association data on which the transitive relationship transfer was based. In the example shown, they are the ENCODES associations (provided by the Entrez Gene database) of the IGF2 human gene with the proteins with AAL55889 or AAY40360 EMBL ID, which are both associated by similarity with the protein with P09565 UniProt AC that (according to the GOA database) is annotated to the Insulin-like growth factor binding biological function with NAS (Non-traceable Author Statement) evidence.

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