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Table 2 Accuracy comparison with existing methods

From: MOST+: A de novo motif finding approach combining genomic sequence and heterogeneous genome-wide signatures

Algorithms

Detection ratio

Succeeded

Co-factors

Motif cluster

MOST

43%

8

3.7

Y

MOST+

45%

11

4.3

Y

DREME

25%

10

5.6

N

Trawler

11%

8

0.6

N

nestedMICA

21%

10

2.1

N

MEME

5%

10

0.9

N

WEEDER

6%

10

0.5

N

CisFinder

76%

10

3.6

Y

HOMER

38%

11

3.0

Y

  1. Columns 2-5: 2) Detection ratio: the number of clusters aligned to motifs in the database divided by the total cluster number found over 13 TFs; 3) Succeeded: numbers of major TFBSs ranked first in the results; 4) Co-factors: the average numbers of unique co-factors found in databases (e-value<0.05 given by TOMTOM) and 5) Motif cluster: whether a clustering step is used to merge results of a method.