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Table 5 ECemble predicted enzymes from reviewed human proteome.

From: Application of a hierarchical enzyme classification method reveals the role of gut microbiome in human metabolism

Gene Name

Accession

$UniProt Annotation

New ECemble Prediction

EC Description of

Enzyme Function

DHRS7

Q9Y394

1.1.-.-

1.1.1.n4*

(-)-trans-carveol dehydrogenase

GFOD1

Q9NXC2

1.-.-.-

1.1.1.n6*

D-chiro-inositol 3-dehydrogenase

FOXRED1

Q96CU9

1.-.-.-

1.1.5.4*

Malate dehydrogenase (quinone)

ALOX12B

O75342

1.13.11.-

1.13.11.12*

Linoleate 13S-lipoxygenase

ALDH8A1

Q9H2A2

1.2.1.-

1.2.1.16*

Succinate-semialdehyde dehydrogenase (NAD(P)(+))

SCCPDH

Q8NBX0

1.-.-.-

1.5.1.10*

Saccharopine dehydrogenase (NADP(+), L-glutamate-forming)

TFB1M

Q9UNQ2

2.1.1.-

2.1.1.182*

16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase

METTL15

A6NJ78

2.1.1.-

2.1.1.199*

16S rRNA (cytosine(1402)-N(4))-methyltransferase

METTL15P1

P0C7V9

2.1.1.-

2.1.1.199*

16S rRNA (cytosine(1402)-N(4))-methyltransferase

PYROXD2

Q8N2H3

1.-.-.-

2.1.1.74*

(FADH(2)-oxidizing)

GOT1L1

Q8NHS2

2.6.1.-

2.6.1.9*

Histidinol-phosphate transaminase

FGGY

Q96C11

2.7.1.-

2.7.1.16*

Ribulokinase

ISPD

A4D126

2.7.7.-

2.7.7.60*

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

GDPD3

Q7L5L3

3.1.-.-

3.1.4.46*

Glycerophosphodiester phosphodiesterase

TLL1

O43897

3.4.24.-

3.4.24.21*

Astacin

TASP1

Q9H6P5

3.4.25.-

3.4.25.2*

HslU--HslV peptidase

ADAL

Q6DHV7

3.5.4.-

3.5.4.2*

Adenine deaminase

IREB2

P48200

None

4.2.1.33*

3-isopropylmalate dehydratase

TYRP1

P17643

1.14.18.-

1.14.11.13**

Gibberellin 2-beta-dioxygenase

HSD11B2

P80365

1.1.1.-

1.3.1.9**

Enoyl-[acyl-carrier-protein] reductase (NADH)

NDOR1

Q9UHB4

1.6.-.-

1.8.1.2**

Sulfite reductase (NADPH)

ENDOV

Q8N8Q3

3.1.26.-

3.1.21.7**

Deoxyribonuclease V

ENPP5

Q9UJA9

3.1.-.-

3.6.1.27**

Undecaprenyl-diphosphate phosphatase

MPPED2

Q15777

3.1.-.-

3.6.1.41**

Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)

THNSL2

Q86YJ6

4.2.3.-

4.2.1.20**

Tryptophan synthase

ALOXE3

Q9BYJ1

5.4.4.-

1.13.11.12***

Linoleate 13S-lipoxygenase

ABHD2

P08910

3.1.1.-

2.3.1.31***

Homoserine O-acetyltransferase

ABHD1

Q96SE0

3.1.1.-

2.3.1.31***

Homoserine O-acetyltransferase

ABHD3

Q8WU67

3.1.1.-

2.3.1.84***

Alcohol O-acetyltransferase

SDR42E1

Q8WUS8

1.1.1.-

5.1.3.20***

ADP-glyceromanno-heptose 6-epimerase

  1. $Current annotation is based on UniProt database
  2. n Preliminary EC numbers include an 'n' as part of the fourth digit in ENZYME database
  3. * Good predictions that complement the current annotations
  4. ** Predictions that differ from the current annotations only at the subclass level
  5. *** Predictions that differ from the current annotations at the class level