Skip to main content
Figure 2 | BMC Genomics

Figure 2

From: Co-modulation analysis of gene regulation in breast cancer reveals complex interplay between ESR1 and ERBB2 genes

Figure 2

Individual and cooperative effects of multiple modulator genes in modulating global gene regulation. (A) Histogram of covariability. The covariability of 14,084,778 gene pairs in 286 samples (grey bars) were approximately normally distributed (red line), with the maximum, minimum, and mean values of 99.88, -77.83, and 0.03, respectively. (B) Histogram of multiple regression p-values from CoMRe. The p-values were significance levels of individual modulator genes in the multiple regression model and roughly followed the uniform distribution. (C) Histogram of multiple regression β values from CoMRe. The β values were approximately normally distributed. (D) Histogram of numbers of significant modulator genes among all gene pairs. 99.36% of all gene pairs were found modulated by less than 5 modulator genes. (E) Percentages of all gene pairs at which each modulator gene appears as a significant modulator. The percentage was calculated against 14,084,778, the total number of gene pairs. The well-studied modulator ESR1was reported as the most significant modulator (in 17.39% of gene pairs), followed by ERBB2and ADAM12.

Back to article page