Table 2 Top co-modulation groups among the 10 candidate modulator genes.
Co-modulation group | Number of modulated gene pairs | Percentagea | Top hub genesb | Number of core modulated gene pairsc | Number of core modulated genesc |
|---|---|---|---|---|---|
None of the 10 modulators | 5,198,160 | 36.91% | RALYL (4253); CALML3 (4095); KLK12 (3920) | 14,067,700 | 5,308 |
ESR1 | 801,229 | 5.69% | NFIX (1092); SMPDL3A (1072); VEGFA (1045) | 10,235 | 964 |
ADAM12 | 579,710 | 4.12% | LUM (1005); MYST4 (993); CHST1 (988) | 81 | 80 |
CCL5 | 556,253 | 3.95% | CTSW (1622); CCL4 (1209); CCR5 (1206) | 3,168 | 405 |
MK167 | 537,860 | 3.82% | CPS1 (1160); GDPD3 (929); KLHDC4 (914) | 251 | 241 |
ERBB2 | 519,905 | 3.69% | MED1 (1012); PGAP3 (1005); STARD3 (1000) | 1,879 | 612 |
MIF | 500,576 | 3.55% | RPS2 (1313); FTL (1200); PRKCSH (1137) | 2 | 4 |
MYC | 476,208 | 3.38% | BOLA1 (884); FOSB (844); SLC38A2 (817) | 12 | 19 |
TP53 | 373,338 | 2.65% | TP53 (1636); RAGE (1005); RABGAP1 (909) | 367 | 371 |
IGF1 | 266,990 | 1.90% | PLA2G2A (672); TNXB (662); CIDEA (659) | 215 | 86 |
RECK | 230,900 | 1.64% | RECK (1693); DNAH3 (1640); OPHN1 (1622) | 459 | 137 |
ESR1−ERBB2 | 199,263 | 1.41% | MIA (780); KRT6B (631); FYCO1 (628) | 407 | 141 |
ESR1−MK167 | 135,164 | 0.96% | AZI1 (753); AQP5 (688); C3ORF37 (515) | 2 | 2 |
ESR1−CCL5 | 122,901 | 0.87% | HOXA10 (539); PXDN (465); APOC2 (462) | 0 | 0 |
ADAM12−CCL5 | 109,845 | 0.78% | CD38 (661); PRF1 (660); IL2RG (544) | 0 | 0 |
ESR1−MYC | 104,650 | 0.74% | KMO (534); ETFA (394); NAAA (362) | 0 | 0 |
ADAM12−ESR1 | 95,542 | 0.68% | WNK1 (290); IGFBP4 (288); MFAP2 (279) | 0 | 0 |
IGF1−MK167 | 79,342 | 0.56% | TTC23 (436); KIT (306); PRPF18 (280) | 0 | 0 |
ADAM12−ERBB2 | 76,759 | 0.54% | MAP7 (347); VCAM1 (270); TRAPPC10 (269) | 0 | 0 |
ADAM12−MYC | 72,520 | 0.51% | FBN1 (259); MARCH5 (241); GADD45B (234) | 0 | 0 |
ESR1−TP53 | 71,837 | 0.51% | CRLF1 (565); PGC (435); ITPKB (317) | 0 | 0 |