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Table 6 Top ten ranked genetic pathways shared between TMAO and CRC.

From: A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat

TMAO ∩ CRC (OMIM)

TMAO ∩ CRC (GWAS)

TMAO ∩ CRC (OMIM) ∩ CRC

(GWAS)

Pathways in cancer

Immune system

Neurotrophin signaling pathway Cell cycle

Wnt signaling

CMYB pathway

Adaptive immune system

MYC activpathway

MARK signaling pathway Hemostasis

Immune system

Cell cycle

Pathways in cancer

Metabolism of proteins

TCA cycle and respiratory electron transport

MYC activpathway

Adaptive immune system

WNT signaling

MAPK signaling pathway Metabolism of lipids and lipoproteins

Immune system

Cell cycle

Pathways in cancer

WNT signaling

Adaptive immune system

MYC activpathway

MAPK signaling pathway Chromosome maintenance Telomere maintenance

Metabolism of lipids and lipoproteins