Figure 1
From: Computational methods and resources for the interpretation of genomic variants in cancer
Number of missense and stop gain somatic mutations in APC and KRAS detected in 220 samples of colon adenocarcinoma from TCGA studies. In blue and orange are reported the nonsynonymous and stop gain somatic variants respectively. For APC we detected a total number of 265 somatic variants 28 of which are nonsynonymous and 150 stop gain. Among the 28 stop-gain variants only 6 are recurrent. For KRAS we detected a total number of 101 somatic variants 97 of which are nonsynonymous. Among the observed nonsynonymous variants 53 are observed in position 12 and only 6 are not recurring.