Skip to main content
Figure 6 | BMC Genomics

Figure 6

From: Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein

Figure 6

Multiple sequence alignment of midasin M-domains with selected magnesium chelatases and integrin I-domains The conserved residues in the MIDAS sequence motifs (hhhhDxSxS, [S/T] and hhhh[S/T]DG) are indicated by ▲ under the alignment. In all midasins and chelatases, the MIDAS-containing domain is located at the COOH-terminus of the protein (asterisk). The Structure line below the alignment indicates the position of secondary structural elements in the I-domain of integrin α2 (pdb: 1AOX_A). The coloring indicates the level of consensus for each residue position in the sets of three midasins, three chelatases, and three integrins, with each set being considered separately. Color key: red/yellow, invariant; blue/blue, majority of identical residues; green/green, majority of highly conserved residues; green/white, weakly conserved residues; gray/white, non-conserved residues. Abbreviations: MIDA, midasin; YEAST, Saccharomyces cerevisiae; GIARD, Giardia intestinalis; BCHD_RHOCA, D-subunit of Mg chelatase from Rhodobacter capsulatus (accession P26157); BCHD_CHLFL, D-subunit of Mg chelatase from Chloroflexus aurantiacus (accession AAG15217); CHLD_ARATH, D-subunit of Mg chelatase from Arabidopsis thaliana (accession Q9SJE1). ITAL, I-domain of integrin αL (accession P20701). ITAM, I-domain of integrin αM (accession P11215); ITA2, I-domain of integrin α2 (accession P17301). All residue numbers indicate position in full-length subunits.

Back to article page