Table 1 Genes encoded within 2 Mb of JA04 in order from telomere (top) to centromere.
From: A transcription map of the 6p22.3 reading disability locus identifying candidate genes
Gene | Gene Size (kb) | MRNA Accession # | # of Exons | Mapping Source | Function |
|---|---|---|---|---|---|
FLJ12671 | 15.885 | NM_030980 | 3 | This paper | Function unknown |
HNRPA1 (pseudogene) | 1.813 | XM_031157 | 1 | This paper | Functions as carriers for RNA during export to the cytoplasm |
P24 | 21.142 | AF418980 | 5 | This paper | Transmembrane protein; may have a role in vesicular trafficking |
RU2AS | 79.995 | AF181722 | 7 | [46] | Cellular defense response |
MRS2L | 20.629 | XM_041317 | 11 | NT_017021a | Transporter protein |
GPLD1 | 61.339 | XM_041310 | 25 | [47] | Hydrolyzes inositol-PO4 linkage in proteins anchored by phosphatidylinositol glycans |
SSADH | 39.639 | NM_001080 | 10 | [48] | Required for 4-aminobutyric acid degradation |
KIAA0319 | 102.051 | XM_011367 | 21 | NT_017021a | Function unknown |
Cytokeratin 8 | 2.206 | XM_069402 | 2 | This paper | Regulation of exocrine pancreas homeostasis |
TRAF | 16.902 | AF223469 | 7 | [49] | Inhibits NF-KappaB activation |
HT012 | 34.662 | AF220186 | 3 | NT_017021a | Uncharacterized hypothalamus protein |
FLJ12619 | 14.192 | XM_041290 | 5 | NT_017021a | Function unknown |
AP3 | 1.667 | BC000804 | 3 | This paper | May be involved in intracellular protein transport |
Geminin | 11.086 | NM_015895 | 9 | NT_017021a | Inhibits DNA replication during cell cycle S, G2, and M phase |
KIAA0386 | 106.682 | AB002384 | 23 | NT_017021a | Stimulates the formation of a non-specific multinucleate syncytium from proliferative cytotrophoblasts during trophoblast differentiation |
Cyclophilin A | 0.81 | XM_098483 | 2 | NT_017021a | May to be involved in protein folding and/or intracellular protein transport |
ASSP2 (pseudogene) | 1.954 | XM_000845 | 1 | This paper | Catalyzes the ATP-dependent ligation of citrulline to aspartate, forms argininosuccinate in the urea cycle |
CMAH | 56.489 | XM_041278 | 15 | [50] | Converts the nucleotide sugar donor N-acetylneuraminic acid to N-glycolylneuraminic acid |
NUP50 | 1.737 | XM_018531 | 1 | NT_017021a | Allows bi-directional transport of macromolecules through the nuclear envelope |
UBE2D2 | 1.732 | XM_030770 | 1 | This paper | Modifies proteins with ubiquitin for degradation |
RPS10 | 1.428 | XM_069039 | 2 | This paper | Ribosomal protein |