Multiple sequence alignment of the 7TM domains of the 7TMR-DISM family. Multiple sequence alignment the 7TMR-DISM family was constructed using T-Coffee  after parsing high-scoring pairs from PSI-BLAST search results. The PHD-secondary structure  is shown above the alignment with | representing an α-helix. The 85% consensus shown below the alignment was derived using the following amino acid classes: hydrophobic (h: ALICVMYFW, yellow shading); small (s: ACDGNPSTV, green) and polar (p: CDEHKNQRST, blue). The limits of the domains are indicated by the residue positions, on each end of the sequence. The two major groups of these receptors, typically associated with either 7TMR-DISMED2s (upper group) or 7TMR-DISMED1s (lower group), are separated by a spacer. The numbers within the alignment are non-conserved inserts that have not been shown. The sequences are denoted by their gene name followed by the species abbreviation and GenBank Identifier (gi). The species abbreviations are as provided in Table 1. This alignment is provided as an additional file in the MS-WORD format (additional file 1).