Phylogenetic tree, domain architectures and gene neighborhoods of the 7TMR-DISM family. Phylogenetic relationships of the 7TMR-DISM domain containing proteins along with the domain architectures are shown. The seed alignment used for constructing the tree was one similar to that shown in Fig. 1. The RELL bootstrap values for the major branches are shown at their base. The thickness of a given branch is approximately proportional to the number of proteins contained within it. Domain architectures of the proteins in each branch of the tree are shown in boxes pointed to by the black arrows. The phyletic pattern of each family is shown, along with the number of proteins (if there are more than one). The gene neighborhood data for some of the genes encoding 7TMR-DISM encoding genes is depicted using block arrows. A red arrow indicates the domain architectures of proteins encoded by each gene. The species abbreviations are as shown in Table 1. Domain abbreviations are: DISMED1 – 7TMR-DISMED1; DISMED2 – 7TMR-DISMED2; A. cyclase-Adenylyl cyclases; GGDEF-GGDEF-motif-containing nucleotide cyclase domains; His Kin – Histidine Kinase; EAL-EAL motif containing cyclic nucleotide phosphodiesterases; REC – Receiver domain; PAS-Ligand binding domain found in Drosophila P eriod clock proteins, vertebrate A ryl hydrocarbon receptor nuclear translocator and Drosophila S ingle minded proteins; ZR, Zinc Ribbon HTH; Helix-Turn-Helix domain (of AraC, OmpR and TetR variety); PP2C – Sigma factor PP2C-like phosphatases ; TPR – etratricopeptide repeats; CTR – Chemotaxis receptor domain; HAMP – domain present in H istidine kinases, A denylyl cyclases, M ethyl-accepting proteins and P hosphatases.