Combined analysis of expression data and transcription factor binding sites in the yeast genome

BMC Genomics

Table 3 Potential a 1-α 2 target sites in ORFs

ORF	Gene	Expression p-val^a	Binding p-val^b	Combined p-val	a1-α 2 ChIP^c	EMSA^d
YKL014C	URB1	0.621	0.042	0.025	-	25×
YGL053W	PRM8	0.291	0.011	0.002	-	5×
YAR031W	PRM9	0.891	0.013	0.012	-	10×
YKL162C		0.782	0.017	0.014	-	10×
YLR310C	CDC25	0.102	0.018	0.002	-	5×
YPL061W	ALD6	0.597	0.018	0.009	-
YBR028C		0.793	0.046	0.036	-
YOL022C		0.563	0.023	0.013	-
YJR016C	ILV3	0.248	0.025	0.006	-
YBR218C	PYC2	0.324	0.027	0.008	-
YFR040W	SAP155	0.234	0.165	0.038	-
YMR269W		0.332	0.049	0.016	-
YJL129C	TRK1	0.297	0.083	0.024	-
YCR053W	THR4	0.607	0.073	0.044	-

^a The ranking of haploid-specific gene expression determined by analysis of microarray data [11].
^b The ranking of potential a 1-α 2 target of haploid-specific genes.
^c A + indicates that the a 1-α 2 binds to the promoter by ChIP assay.
^d Relative binding affinity in fold decrease in affinity compared to the HO(10) binding site.

ISSN: 1471-2164