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Figure 6 | BMC Genomics

Figure 6

From: Performance evaluation of commercial short-oligonucleotide microarrays and the impact of noise in making cross-platform correlations

Figure 6

Power analysis estimating the number of technical array replicates needed to achieve a reasonable level of statistical power or confidence for CodeLink (blue) and GeneChip (red) when noise was included (solid diamonds) or excluded (open diamonds). For both graphs the alpha was set at 0.01. (A) Relationship between power and arrays necessary to statistically discriminate two-fold changes in expression. To achieve a power of 0.90 using all 10,763 genes, 3 arrays are minimally necessary for CodeLink while 8 are required for GeneChip. However, when noise is excluded, both GeneChip and CodeLink require only 1 array to achieve this same level of power. In fact, when noise is excluded, 1 array for both GeneChip and CodeLink has a power of 0.99 to detect two-fold changes in expression. B.) In order to detect 1.5 fold changes in expression, at a 0.90 power, when noise is excluded, CodeLink minimally requires 2 arrays while GeneChip requires 3.

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