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Table 1 General transcription factors predicted in Plasmodium falciparum

From: Prediction of the general transcription factors associated with RNA polymerase II in Plasmodium falciparum: conserved features and differences relative to other eukaryotes

Factors

H. sapiens

S. cerevisiae

P. falciparum

Nuclear signals prediction

Expression pattern

    

NLS

NES

Micro-array

Proteomic data

TFIIA α

P52655

P32773 (TOA1)

MAL7P1.78 +

-

-

G

-

TFIIA β

       

TFIIA γ

P52657

P32774 (TOA2)

PFL2435w *+

-

-

T,Sc

-

   

PFI1630 *

+

-

G

-

TFIIB

Q00403

P29055

PFA0525w

-

-

All stages

-

TFIID TBP

P20226

P13393

PFE0305w

-

-

R

-

TFIID TAF1

P21675 (TAF250)

P46677 (TAF145)

PFL1645w

+

-

S,LT

S,G

TFIID TAF2

gi:4507347 (TAF150)

P23255 (TAF150)

MAL7P1.134

+

+

R,T

S

TFIID TAF5

Q15542 (TAF100)

P38129 (TAF90)

?

    

TFIID TAF7

Q15545 (TAF55)

Q05021 (TAF67)

PFI1425w

+

+

R,S

-

TFIID TAF14

P42568 (ENL/AF-9)

P35189 (TAF30)

?

    

TFIID TAF4

O00268 (TAF135)

P50105 (TAF48)

?

    

TFIID TAF12

Q16514 (TAF20)

Q03761 (TAF68/61)

?

    

TFIID TAF6

P49848 (TAF80)

P53040 (TAF60)

?

    

TFIID TAF9

Q16594 (TAF31)

Q05027 (TAF17)

?

    

TFIID TAF11

Q15544 (TAF28)

Q04226 (TAF40)

?

    

TFIID TAF13

Q15543 (TAF18)

P11747 (TAF19)

?

    

TFIID TAF3

gi:13374079 (TAF140)

Q12297 (TAF47)

?

    

TFIID TAF8

gi:31323620 (TAF43)

Q03750 (TAF65)

?

    

TFIID TAF10

Q12962 (TAF30)

Q12030 (TAF25)

PFE1110w

-

+

R, Sc

-

TFIIE α

P29083

P36100

MAL7P1.86 +

+

+

Sc

-

TFIIE β

P29084

P36145

MAL13P1.360 *

+

-

ND

-

TFIIF α

P35269 (RAP74)

P41895 (Tfg1)

?

    

TFIIF β

P13984 (RAP30)

P41896(Tfg2)

PF11_0458 *

-

+

R,G

-

TFIIH core p62/TFB1

P32780 (p62)

P32776 (TFB1)

MAL3P7.42 *+ (Chr3.phat_258)

+

+

R,T

-

TFIIH core p52/TFB2

Q92759 (p52)

gi:6325135 (TFB2)

PFL2125c

+

+

R,T,Sc

-

TFIIH core p44/SSL1

Q13888 (p44)

Q04673 (SSL1)

MAL13P1.76

+

+

R,T

-

TFIIH core p34/TFB4

Q13889 (p34)

Gi:6325313

PF13_0279

-

+

T

-

TFIIH core TFB5

Gi:55665883

Gi:13129164

PF14_0398

-

-

R, T, G

-

TFIIH core XPB/SSL2-RAD25

P19447 (XPB)

Q00578 (SSL2/RAD25)

PF10_0369

+

-

G

S

TFIIH XPD/RAD3

P18074 (XPD)

P06839 (RAD3)

PFI1650w

+

+

R,T,G

G

TFIIH CAK MAT1/TFB3

P51948 (MAT1)

Gi:6320668 (TFB3)

PFE0610c

+

-

R,T

-

TFIIH CAK Cdk7/KIN28

P50613 (CDK7)

P06242 (KIN28)

? $

    

TFIIH CAK Cyclin H/CCL1

P51946 (cyclin H)

P37366 (CCL1)

? $

    
  1. The general transcription factors which were identified in this report are underlined and shown in bold; * and + indicate similarities which were identified in this report after assessing PSI-BLAST marginal similarities at the sequence 2D level or after extending the comparison at the 2D level outside the limits primarily defined by PSI-BLAST, respectively. The Swiss-Prot accession numbers are given for the human and yeast sequences. When a Swiss-Prot identifier is not available, the genbank identifier (gi) is indicated in italics instead. The references of the human TAF3 and TAF8 sequences can be found in [50] and [100], respectively. $ : see text for comments on these putative homologues of Cdk7/KIN28 and cyclin H/CCL1. The presence of nuclear localization sequences (NLS 102), nuclear export sequences (NES [103]), and the expression of these predicted general transcription factors using microarray and proteomics on different parasite stages ([9–11, 89]) are indicated. G: gametocyte, T: trophozoite, LT: late trophozoite, Sc: schizonte, R: ring, (-): absent, (+): present, (?): cannot be found.