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Figure 1 | BMC Genomics

Figure 1

From: A rigorous method for multigenic families' functional annotation: the peptidyl arginine deiminase (PADs) proteins family example

Figure 1

Phylogenetic tree built with PAD and NR database, with Danio-rerio's PAD sequence in out-group. This tree is the fusion on the NJ topology, of three phylogenetic trees built based on N eighbour Joining (NJ) [36], Maximum P arsimony (MP) [39], and Maximum L ikelihood (ML) [40] methods. The tree is labelled npl-A at the first root (for N j, mP, mL, with A ll topology congruence tests passed). For each node, bootstrap values are reported for each npl method. A "*" means that the bootstrap value was under 50%. PAD protein from Danio-Rerio is co-orthologous to all others PADs. In mammals five groups of orthologs are found, named PAD-1, PAD-2, PAD-3, PAD-4 and PAD-6. PAD-2 paralogy group is the best conserved as it evolved slower than the others.

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