Table 1 Distribution of (TG/CA)n repeats in large gene families
Functional class and gene families | Chromosomal Distributiona | Average Gene Length (kb)b | Genes in the family | Proportion of Genes with (TG/CA)n repeats | Number of Genes with (TG/CA)n repeats in three categories | Average number of repeats per gene in three categories | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | Type I | Type II | Type III | Type I | Type II | Type III |
Cell cycle classc(1) | ||||||||||
Histone proteins family | Dispersed | 3.55 | 76 | 7.9 | 4 | 4 | 0 | 1.7 | 0.7 | 0 |
Immune and related functions class (9) | ||||||||||
Interleukins | Dispersed | 14.67 | 43 | 32.6 | 9 | 6 | 2 | 1.3 | 0.9 | 0.1 |
Serine (or cysteine) proteinase inhibitor family | Dispersed | 17.87 | 32 | 50 | 12 | 9 | 2 | 1.4 | 0.8 | 0.2 |
Tumor necrosis factor (ligand) superfamily | Dispersed | 23.49 | 38 | 63.2 | 21 | 14 | 1 | 1.9 | 0.9 | 0.1 |
CD antigens | Dispersed | 26.96 | 54 | 46.3 | 20 | 11 | 3 | 1.9 | 1.3 | 0.3 |
Immunoglobulin heavy chains | Intrachromosomal | 0.38 | 162 | 0.6 | 1 | 0 | 0 | 1 | 0 | 0 |
Immunoglobulin kappa chains | Intrachromosomal | 0.55 | 73 | 5.5 | 1 | 3 | 0 | 0.3 | 3 | 0 |
Immunoglobulin lambda chains | Intrachromosomal | 0.35 | 88 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interleukin receptors family | Dispersed | 29.77 | 32 | 59.4 | 17 | 10 | 0 | 3.4 | 0.9 | 0 |
T cell receptor beta chains | 84 Intrachromosomal, 9 Dispersed | 0.42 | 94 | 9.6 | 5 | 3 | 1 | 0.8 | 0.3 | 0.1 |
Information class (6) | ||||||||||
Homeo box | Dispersed | 5.48 | 40 | 25 | 6 | 6 | 1 | 1.2 | 0.9 | 0.2 |
Eukaryotic translation initiation factor | Dispersed | 36.54 | 33 | 45.5 | 13 | 10 | 3 | 2.1 | 0.9 | 0.2 |
Zinc finger protein family | Dispersed | 30.33 | 200 | 42.5 | 63 | 44 | 6 | 2.2 | 1.1 | 0.1 |
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptides | Dispersed | 43.44 | 32 | 62.5 | 17 | 8 | 2 | 1.5 | 0.6 | 0.1 |
Ribosomal protein genes | Dispersed | 4.94 | 96 | 6.3 | 6 | 0 | 0 | 1 | 0 | 0 |
Mitochondrial ribosomal protein genes | Dispersed | 16.92 | 74 | 23 | 14 | 12 | 1 | 1.8 | 0.9 | 0.1 |
Metabolism class (2) | ||||||||||
Cytochrome P450 superfamily | Dispersed | 31.34 | 45 | 46.7 | 15 | 11 | 2 | 1.9 | 1 | 0.1 |
Proteasome subunit genes | Dispersed | 25.64 | 40 | 32.5 | 11 | 8 | 0 | 1.5 | 0.8 | 0 |
Signaling and Communication class (8) | ||||||||||
G protein-coupled receptor family | Dispersed | 24.71 | 98 | 33.7 | 26 | 19 | 6 | 2.3 | 1.5 | 0.2 |
Tripartite motif-containing family | Dispersed | 29.29 | 40 | 60 | 19 | 12 | 2 | 1.6 | 0.8 | 0.1 |
Solute carrier family | Dispersed | 59.19 | 223 | 62.8 | 134 | 87 | 22 | 2.9 | 1.5 | 0.2 |
RAS oncogene family | Dispersed | 39.92 | 60 | 65 | 38 | 17 | 4 | 1.8 | 0.7 | 0.1 |
ATP-binding cassette transporters gene family | Dispersed | 73.85 | 44 | 68.2 | 29 | 24 | 4 | 3.6 | 2.5 | 0.3 |
Guanine nucleotide binding protein (G protein) polypeptide genes | Dispersed | 58.83 | 32 | 59.4 | 18 | 12 | 5 | 3.3 | 1.9 | 0.4 |
Potassium voltage-gated channel genes | Dispersed | 104.95 | 38 | 57.9 | 17 | 16 | 6 | 8.6 | 4.4 | 0.5 |
Protein phosphatase subunit genes | Dispersed | 65.62 | 59 | 57.6 | 27 | 22 | 7 | 2.9 | 1.8 | 0.3 |
Structure and motility class (1) | ||||||||||
Collagen family | Dispersed | 132.83 | 37 | 86.5 | 29 | 23 | 10 | 5.7 | 2.3 | 0.4 |