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Table 4 Mean CS in mouse, in paralogues and KA/KS values for dominant and recessive disease genes by GO slim category

From: Differences in the evolutionary history of disease genes affected by dominant or recessive mutations

 

CS mouse

 

nD

Disease

Disease dominant

Disease recessive

Enzyme regulation

0.778

0.790

0.818

0.755

Transcription regulation

0.800

0.860

0.871

0.824

Nucleic acid binding

0.795

0.835

0.851

0.803

Catalysis

0.809

0.819

0.832

0.815

Signal transduction

0.751

0.748

0.776

0.708

Structural molecule

0.828

0.831

0.838

0.815

Transporter

0.824

0.848

0.862

0.841

Carrier

0.838

0.881

0.884

0.880

 

CS paralogues

 

nD

Disease

Disease dominant

Disease recessive

Enzyme regulation

0.374

0.272

0.300

0.236

Transcription regulation

0.353

0.422

0.440

0.359

Nucleic acid binding

0.358

0.370

0.431

0.250

Catalysis

0.381

0.355

0.430

0.331

Signal transduction

0.383

0.347

0.406

0.261

Structural molecule

0.449

0.482

0.595

0.207

Transporter

0.424

0.400

0.539

0.331

Carrier

0.425

0.432

0.571

0.402

 

K A /K S chimpazee

 

nD

Disease

Disease dominant

Disease recessive

Enzyme regulation

0.163

0.233

0.223

0.251

Transcription regulation

0.170

0.144

0.109

0.253

Nucleic acid binding

0.188

0.164

0.149

0.190

Catalysis

0.185

0.179

0.150

0.189

Signal transduction

0.213

0.173

0.138

0.238

Structural molecule

0.201

0.183

0.155

0.250

Transporter

0.176

0.166

0.082

0.213

Carrier

0.170

0.197

0.123

0.213