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Table 3 Multivariate analysis of mortality and DMFP risk factors and BCMP11/ABCC11.

From: Discovery and validation of breast cancer subtypes

 

Overall survival

Distant metastasis-free probability

 

Hazard ratio (95% confidence interval)

p-value

Hazard ratio (95% confidence interval)

p-value

BCMP11/ABCC11: Group 2 vs. Group 1

2.124 (1.0923 – 4.130)

0.0260

1.759 (0.948 – 3.263)

0.073

BCMP11/ABCC11: Group 3 vs. Group 1

2.155 (1.1874 – 3.913)

0.0120

1.452 (0.817 – 2.580)

0.200

Age (decade)

0.688 (0.4792 – 0.988)

0.0430

0.736 (0.523 – 1.035)

0.078

Tumor diameter (cm)

1.022 (0.9967 – 1.048)

0.0890

1.034 (1.010 – 1.058)

0.006

Lymph node status (positive node)

1.010 (0.8309 – 1.228)

0.9200

1.045 (0.886 – 1.234)

0.600

Tumor grade: Poorly diff. vs. Intermediate

1.185 (0.6586 – 2.131)

0.5700

0.979 (0.560 – 1.713)

0.940

Tumor grade: Well diff. vs. Intermediate

0.240 (0.0828 – 0.698)

0.0088

0.403 (0.190 – 0.855)

0.018

Vascular invasion: 1–3 vessels vs. ≥ 4 vessels

0.627 (0.2150 – 1.829)

0.3900

0.530 (0.198 – 1.424)

0.210

Vascular invasion: 0 vessels vs. ≥ 4 vessels

0.589 (0.1322 – 2.621)

0.4900

0.560 (0.145 – 2.158)

0.400

Mastectomy vs. breast conserving therapy

1.119 (0.6933 – 1.807)

0.6400

1.193 (0.750 – 1.895)

0.460

Chemo and hormonal therapy v. no adjuvant therapy

0.724 (0.3281 – 0.1596)

0.4200

0.502 (0.246 – 1.022)

0.057

  1. Results of the multivariate analysis of mortality risk factors (left) and DMFP risk factors (right). The group classifications determined by the BCMP11 and ABCC11 gene pair are included. The p-values less than 0.05 are in bold. The p-values significant at an α = 0.10 level but not at an α = 0.05 significance level are in italics.