A biological question and a balanced (orthogonal) design: the ingredients to efficiently analyze two-color microarrays with Confirmatory Factor Analysis

Table 2 Comparison of our gene list with gene lists described in literature

Reference: Cell lines	A2780 vs. CP70 + C30 + C200		CP70 vs. C30 + C200
	Up-regulated	Down-regulated	Down-regulated*
[13]: 6 cisplatin resistant cell pairs, including A2780 and CP70	JUN (↑) and IFITM1 (↓)	MRC2(↓)
[14]: A2780 and oxaliplatin resistant C10B	FER1L3 (↑), LIPA (↑), IFITM1 (↑), NMI (↑) and ALCAM (↑)	SOC2 (↓), MID1(↓), TFPI (↓), MMRN (↓), CCR1 (↓) and NID2 (↑)	MMP3 (↑), SPARC (↑), FER1L3 (↑), TM4SF1 (↓), CRIM1 (↓) and PEG10 (↓)
[16]: 4 oxaliplatin resistant cell pairs, including A2780 and R4	NFE2L1 (↑), IFITM1 (↓)	TIP120B (↑)	TIMP2 (↑), COTL1 (↑), IL1R1 (↑), SPARC (↑) and SLC4A2 (↓)
[15]: A2780, cisplatin resistant ACR6 and ACRP		S100A11 (↓) and SLC25A6 (↓)	PEG10 (↑), TMSB4X (↓) and COL5A2 (↓)

The arrows behind the genes indicate whether the gene was up-regulated (↑) or down-regulated (↓) in the cisplatin/oxaliplatin resistant subline(s) compared to the cisplatin/oxaliplatin sensitive parental cell line according to microarray or SAGE data of other groups. * The genes selected from factor 2 that were also described in literature were all down-regulated in C30 + C200 compared to CP70.

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