Figure 3
Robustness of random and targeted hub deletion mutants to mutational stress. Average of median values for each of the 30 secondary mutations made in each strain is plotted. Error bars indicate standard errors. Reference strain (ref), solid square; random disruption strains, solid circles; targeted hub disruption strains, hollow circles. Solid line indicates mean of random disruption strains; dotted line indicates mean of targeted hub disruption strains.