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Figure 1 | BMC Genomics

Figure 1

From: CoryneRegNet: An ontology-based data warehouse of corynebacterial transcription factors and regulatory networks

Figure 1

The biological concept of CoryneRegNet. The model presents the hierarchical and modular network structure of transcriptional regulatory interactions in C. glutamicum. It consists of five distinct transcription factor modules and a module containing the main and alternative sigma factors involved in differential gene expression by sigma factor competition [7]. A top level regulator is the hyperphosphorylated guanosine nucleotide ppGpp, involved in sensing the quality of the environment and the cellular resources [7]. The amount of ppGpp determines the cellular program and the role of sigma factor competition in global regulation of gene expression.

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BMC Genomics

ISSN: 1471-2164

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