Figure 5From: Comparative genomics of fungal allergens and epitopes shows widespread distribution of closely related allergen and epitope orthologuesStructural models showing conservation of allergen and epitope structure between enolase allergens and allergen homologues. Conserved non-epitope structure is shown in blue. Epitope structure that is identical in all allergens studied and also identical in allergen-like proteins is shown in red. Epitope amino acids not conserved between experimentally determined cross-reacting allergen epitopes are shown in green and amino acids differing from epitope in allergen-like proteins are shown in yellow. A: View of enolase Cla h 6 predicted structure as a space fill model showing conserved epitope present in all fungi. B: Reverse view of Cla h 6 showing epitopes conserved in ascomycetes C: Reverse view of Cla h 6 showing epitopes conserved in yeasts, C. albicans, C. tropicalis, S. cerevisiae and R, mucilaginosa. D: Reverse view of Cla h 6 showing epitopes conserved in basidiomycetes C. cinereus C. neoformans and U. maydis E: Representative enolase structures consisting of Cla h 6, Sac c enolase and C. cinereus enolases superimposed. F: Enolase epitope structure for ascomycetes. The exposed epitope structure is displayed as ribbon and the buried portion of the epitope is shown as a blue CA trace. G: Enolase epitope structure for yeasts. The exposed epitope structure is displayed as ribbon and the buried portion of the epitope is shown as a blue CA trace. H: Enolase epitope structure for basidiomycetes. The exposed epitope structure is displayed as ribbon and the buried portion of the epitope is shown as a blue CA trace. I: Structure and amino acid sequence of the divergent loop in yeast and basidiomycete epitopes (circled in C, D and E)Back to article page