Table 5 Genes that were significantly altered by at least 1.4-fold in response to BaP in both MCF-7 and HepG2 cells
IMAGE Clone ID | Gene Symbol | Genbank Accession Number | Gene Title | Biological Process | Direction of expression alteration2 | Pearson correlation with DNA adducts | ||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | MCF-7 | HepG2 | MCF-7 | HepG2 |
1473304 | AKR1C3 | BQ939577 | Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) | cell proliferation; prostaglandin metabolism | ↑ | ↑ | 0.261 | -0.065 |
810724 | IER3 | BM994398 | Immediate early response 3 | anti-apoptosis; cell growth and/or maintenance; embryogenesis and morphogenesis; morphogenesis | ↑ | ↑ | 0.192 | 0.805 1 |
789376 | TXNRD1 | NM_003330 | Thioredoxin reductase 1 | electron transport; heavy metal sensitivity/resistance; signal transduction | ↑ | ↑ | 0.849 | 0.253 |
768443 | MGST1 | AK123482 | Microsomal glutathione S-transferase 1 | prostaglandin metabolism | ↑ | ↑ | 0.599 | 0.815 |
196992 | AKR1C1 | AK095239 | Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) | xenobiotic metabolism | ↑ | ↑ | 0.383 | 0.078 |
214006 | HIST1H2BG | NM_003518 | Histone 1, H2bg | nucleosome assembly; regulation of transcription\, DNA-dependent | ↓ | ↓↑ | -0.780 | -0.201 |
1842170 | HIST1H4B | BX102654 | Histone 1, H4b | nucleosome assembly; regulation of transcription\, DNA-dependent | ↓ | ↓↑ | -0.620 | -0.173 |
129467 | HIST1H2BJ | BF983642 | Histone 1, H2bj | nucleosome assembly; regulation of transcription\, DNA-dependent | ↓ | ↓↑ | -0.709 | -0.193 |
268891 | HIST1H3D | BQ051491 | Histone 1, H3d | embryogenesis and morphogenesis; nucleosome assembly | ↓ | ↓↑ | -0.896 | -0.214 |
263087 | CRY1 | AK125915 | Cryptochrome 1 (photolyase-like) | DNA repair; circadian rhythm; vision | ↑ | ↑ | 0.805 | 0.215 |
140997 | GDF15 | BQ883534 | Growth differentiation factor 15 | signal transduction | ↑ | ↑↓ | 0.940 | 0.716 |
273392 | PIGF | BM558246 | Phosphatidylinositol glycan, class F | GPI anchor biosynthesis | ↑ | ↑ | 0.908 | 0.847 |
376772 | RPS27L | BC047648 | Ribosomal protein S27-like | cell proliferation; protein biosynthesis; signal transduction | ↑ | ↑ | 0.944 | 0.380 |
1461138 | HIST1H4C | CD048335 | Histone 1, H4c | nucleosome assembly; regulation of transcription\, DNA-dependent | ↓ | ↓↑ | -0.706 | -0.156 |
205819 | CPM | NM_001874 | Carboxypeptidase M | aromatic compound metabolism; morphogenesis; proteolysis and peptidolysis | ↑ | ↑ | 0.930 | 0.768 |
1673711 | GOLGA1 | U51587 | Golgi autoantigen, golgin subfamily a, 1 |  | ↑↓ | ↑ | -0.194 | -0.206 |
166273 | CDKN1A | NM_078467 | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | cell cycle arrest; induction of apoptosis by intracellular signals; negative regulation of cell proliferation; oncogenesis; regulation of CDK activity | ↑ | ↑ | 0.947 | 0.713 |
324356 | NQO1 | NM_000903 | NAD(P)H dehydrogenase, quinone 1 | electron transport; nitric oxide biosynthesis; response to toxin; synaptic transmission\, cholinergic; xenobiotic metabolism | ↑ | ↑ | 0.884 | -0.023 |
49442 | TXNRD1 | NM_003330 | Thioredoxin reductase 1 | electron transport; heavy metal sensitivity/resistance; signal transduction | ↑ | ↑ | 0.866 | 0.003 |
233273 | STOM | NM_004099 | Stomatin |  | ↑ | ↑ | 0.925 | 0.886 |
25398 | UNC84A | BX640866 | Unc-84 homolog A (C. elegans) |  | ↓ | ↓↑ | -0.662 | -0.097 |
731750 | TAF6L | BC008785 | TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa | chromatin remodeling; regulation of transcription from Pol II promoter; transcription initiation | ↓ | ↓↑ | -0.802 | -0.210 |
381786 | MAK | NM_005906 | Male germ cell-associated kinase | protein amino acid phosphorylation; spermatogenesis | ↑ | ↑ | 0.869 | 0.493 |
323511 | C7ORF36 | BX648555 | Chromosome 7 open reading frame 36 |  | ↑ | ↑ | 0.917 | 0.567 |
760246 | BLOC1S2 | NM_001001342 | Biogenesis of lysosome-related organelles complex-1, subunit 2 |  | ↑ | ↑ | 0.971 | 0.886 |
233279 | SCD | NM_005063 | Stearoyl-CoA desaturase (delta-9-desaturase) | fatty acid biosynthesis | ↓ | ↓ | -0.372 | -0.482 |
24032 | CRADD | AL832705 | CASP2 and RIPK1 domain containing adaptor with death domain | induction of apoptosis via death domain receptors; signal transduction | ↑ | ↓ | 0.359 | 0.420 |