Figure 2

Gene copy numbers in relation to gene expressions. A, Gene copy number relative to model DNA content (log₂ratio) versus position on chromosome 17 (left panel) and chromosome X (right panel), demonstrating gain of PDK2 and MRPS23 (chromosome 17) and loss of MSN (chromosome X) in two different cervical tumors. Each point represents the data for a BAC clone on the genomic microarray. For identification of gains and losses the relative copy number of neighboring clones was always considered in addition to that of the clone of interest. All amplified or deleted regions contained at least three clones. B, Gene expressions (absolute scale) in 47 tumors with loss, no aberration (normal), or gain of LSM3, ANXA4, MSN, MRPS23, FLJ13291, MBNL2, and MGC14151. These genes were the ones with a significant correlation between gene expression and copy number. The chromosomal location of the genes is listed in Table 1. Columns, mean values for all tumors in the groups; bars, standard errors. P-values for the correlations and number of tumors in each group are indicated.