Figure 7

Known ACSs' locations relative to ORC and MCM2 peaks. A. Distance of known ACSs to closest ORC peak and MCM2 peak. B. Relative locations of ACS and ORC peak or MCM2 peak. The x-axis indicates the coordinates of probes on chromosomes in kilobases. The y-axis indicates signal strength by Z-value. The red tick attached to the top axis denotes the ORC or MCM2 peak and the black tick denotes the ACS location. The blue bars represent the Z-value at specified probe coordinates. The red and green lines indicate the smoothed Z-value (sZ) and average Z-value (avgZ) respectively. The horizontal red bar marks the regions called by HMM. For ARS305 and ARS605 both the ORC and MCM2 peaks are very close to the ACS location; for ARS309 and ARS604 the ORC peaks are located close to the ACS, but the MCM2 peaks are quite far due to shifted signal; ARS601/ARS602 and ARS310 have multiple proximate ACSs but do not confer multiple peaks in the data. Many ARSs show missing probes in the ACS region (15 out of 31 known ACSs have missing probes corresponding to the ACS).