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Figure 3 | BMC Genomics

Figure 3

From: Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genus

Figure 3

Comparison of huntingtin gene structure between Ciona intestinalis (upper line) and Homo sapiens (lower line). Only protein-coding regions are indicated. Exons are represented by boxes, with upper numbers indicating exon numbering and inner number indicating exon length (in bp). Box size is unrelated to exon length. Square bracket: exon-block (see text). Yellow box: equivalent exon (see text). Gray box: exon belonging to an exon-block (see text). Introns positionally conserved in the two species are represented by dashed lines, in black for identical intron position, in red for slipped position (changes ≤ 18 bp). Intron phase is reported between dashed lines as a single number if common to the two species. Boxed phase number indicates that intron phase is not conserved in one vertebrate species (see text). Blue boxes below or above the gene structure indicate exons with length differences > 12 bp in vertebrates (below) or in the Ciona genus (above). Letters inside blue boxes indicates the species where the size difference is observed: M, difference between mammals and other-vertebrates; NM, difference within non-mammalian vertebrates; F, difference between fishes and other-vertebrates; G, difference only in Gallus. Arrows indicate the 5% longest introns in at least one vertebrate species (below), and in the Ciona genus (above). AS: alternative splicing experimentally identified in C. intestinalis. PuAS: putative alternative splicing identified "in silico" in Gallus, Xenopus and pufferfishes. Sp: presence of lineage-specific sequences only in non-mammalian species (SpNM) or only in Ciona (SpC).

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