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Table 3 Ascidian and human HEAT repeats mapped on the protein sequence of the corresponding species.

From: Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genus

Species

HEAT name

REP E-value

Htt region

Location

Sequence

C. intestinalis

     
 

A1

0.0005

N-term

58–96

PGLLAVSVETLLQSCADDNADVRLNANECLNRLIKGLYE

 

A2

5.96E-06

N-term

139–177

RPYILNLLPCLCRISQREEDGVQETLGLSLVKIFKILGP

 

A3

1.35E-06

N-term

181–219

ESEIQGLLASFLKNLSHKSATMRRTACVCLHSVILNCRK

 

B4

6.19E-06

N-term

682–720

QSLSHQALSIALKCLCDDDLRLRKTAAATIVTMPTSFPT

 

c

2.30E-06

Central

867–905

SQQQFGILPFVMSLLHSAWLPLDVTAHSDALVLAGNLVA

 

E1

1.26E-06

Central

1341–1378

QGSASHVIPAMQPIIHDI.YVVRASSKNEPPEVTTQREV

 

g1

9.05E-06

C-term

2771–2809

ARVMSKVLPSMLDDFFPAQDIMNKIIAEFISTLQPFPAS

 

g2

1.46E-06

C-term

2864–2904

NRWISSMVPLIISRVHDPTLDVDWTCFCKAAVDFYTCQLSE

C. savignyi

     
 

A1

2.92E-07

N-term

58–96

PGLLAVSVETLLQSCADENADVRLNSNECLNRVIKGLYD

 

A2

0.0001

N-term

139–177

RPYILNLLPCLCRISQREEDAVQEVLSSSLAKIFIVLGA

 

A3

2.52E-06

N-term

181–219

ESEIQGLLASFLKNLSHKSPTVRRTACICLHSILTNSRK

 

B4

1.53E-06

N-term

692–730

KSIAQKALSIALECLCDEDTRLRKTSSAAIVSMATSYPT

 

c

1.46E-06

Central

876–914

AQQQFGILPIVMSLLRSAWLPLDVTAHSDALVLAGNLIA

 

E1

-

Central

1352–1389

QGSASHVIPAMQPITHDI.FVVRGSLKNEPPEVTTQREV

 

g1

1.27E-06

C-term

2770–2808

ARVMSKILPSMLDDFFPAQEIMNKIIAEFISTLQPFPGS

 

g2

-

C-term

2864–2903

RWISSMVPLIISRSHDPSLDRNWTCFCKSAVDFYTCQLSE

Homo sapiens

     
 

A1

4.75E-07

N-term

124–162

QKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMD

 

A2

0.0001

N-term

205–243

RPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGN

 

A3

5.48E-07

N-term

247–285

DNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRR

 

a4

*

N-term

291–329

SWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQ

 

a5

7.77E-06

N-term

318–362

LTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYEL

 

b1

*

N-term

745–783

EYPEEQYVSDILNYIDHGDPQVRGATAILCGTLICSILS

 

b2

1.04E-06

N-term

803–841

TFSLADCIPLLRKTLKDESSVTSKLACTAVRNCVMSLCS

 

b3

*

N-term

842–880

SSYSELGLQLIIDVLTLRNSSYWLVRTELLETLAEIDFR

 

B4

6.69E-08

N-term

904–942

KLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPKLFY

 

b5

9.05E-06

N-term

984–1025

RIYRGYNLLPSITDVTMENNLSRVIAAVSHELITSTTRALTF

 

d

5.62E-06

Central

1425–1463

RLFEPLVIKALKQYTTTTCVQLQKQVLDLLAQLVQLRVN

 

E1

*

Central

1534–1575

RKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVS

 

e2

*

Central

1610–1648

RQIADIILPMLAKQQMHIDSHEALGVLNTLFEILAPSSL

 

e3

*

Central

1670–1710

TVQLWISGILAILRVLISQSTEDIVLSRIQELSFSPYLISC

 

f

3.51E-06

C-term

2798–2836

DDTAKQLIPVISDYLLSNLKGIAHCVNIHSQQHVLVMCA

  1. HEAT repeats are named according to their relative position along the chordate aligned sequences, using the same letter for repeats closer than 45 amino acids. Orthologous HEAT repeats conserved in ascidians and human share the same name, and are reported in upper case. The Expectation values (E-value) was calculated by the REP program [62]. Htt regions defined as in Methods. Absolute position of the HEAT repeats in the corresponding protein sequence is reported in the "Location" column. Dash: REP E-value not statistically significant. Asterisk: HEAT repeats originally described in Andrade and Bork [18] but not identified by the REP program as statistically significant [62].
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BMC Genomics

ISSN: 1471-2164

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