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Table 2 Cross-species comparison of gene essentiality between human and S. cerevisiae.

From: Further understanding human disease genes by comparing with housekeeping genes and other genes

 

Total

Essential

Non-essential

Unknown

Homologs of UEHGs

384 (20.2% of UEHGs)*

138 (35.9%) (7.3% of UEHGs)*

242(63.0%)

4(1.1%)

Homologs of disease genes

196 (9.8% of disease genes)*

51 (26.0%) (2.5% of disease genes)*

142(72.5%)

3(1.5%)

Homologs of other genes

1005 (3.5% of other genes)*

379 (37.7%) (1.3% of other genes)*

618(61.5%)

8(0.8%)

No homologs

4641

505 (10.9%)

3427(73.8%)

709(15.3%)

Total yeast genes

6179

1058 (17.1%)

4397(71.2%)

724(11.7%)

  1. Yeast genes are mapped to three human gene groups by homologous mapping. The first three rows are for each human gene group and the fourth row is for yeast genes without human homologous genes. The last row summarizes all the yeast genes. The first column lists the number of homologous genes found for each human gene group and the fractions with respect to the number of human genes in the corresponding group (show in brackets marked with *). The following columns list the number of yeast essential, non-essential, and unknown genes for each human gene group. The fractions with respect to the number of homologs found in each group are shown in brackets. In the second column, the fraction of homologous essential genes over the human genes in each group is given in the bracket with *.