Figure 1

Conservation of syndecan cytoplasmic domains. Amino acid sequences of syndecan cytoplasmic domains from different species were aligned in ClustalW. The alignment is presented in Boxshade 3.2. Black shading shows identical amino acids; gray indicates conservative substitutions and no shading indicates unrelated amino acids. V = variable region and the very highly-conserved leucine and tyrosine residues are indicated by asterisks. The central hypervariable region (13) is also indicated. Key: Ac, Anthocidaris crassispina; Ap, Acropora palmata; At, Acropora tenuis; Bf, Branchiostoma floridae; Ce, Caenorhabditis elegans; Ci, Ciona intestinalis; Cs, Ciona savignyi; Dm, Drosophila melanogaster; Dr, Danio rerio; Es, Euprymna scolopes; Gg, Gallus gallus; Hm, Hydra magnipapillata; Hs, Homo sapiens; Mj, Marsupenaeus japonicus; Mm, Mus musculus; Nv, Nematostella vectensis; Rp, Rhipicephalus appendiculatus; Sm, Schmidtea mediterranea; Sp, Strongylocentrotus purpuratus; Tn, Tetraodon nigroviridis; Xl, Xenopus laevis; Xt,Xenopus tropicalis. All syndecans are abbreviated as S.