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Table 3 Gene array analysis for adipogenesis, osteogenesis and myogenesis pathways

From: Transcriptional profiling of mesenchymal stromal cells from young and old rats in response to Dexamethasone

GeneID

Name

Probe_ID

Fold change

   

YT/YU

OT/OU

Cluster A

Angiogenesis

114111 a

vascular endothelial growth factor

1368463_at

3.452121

1.502053

24617 a

Serine/cysteine proteinase inhibitor1

1368519_at

5.822078

0.845776

25261 a

Inhibitor of DNA binding 1, helix-loop-helix protein

1387028_a_at

3.49452

0.986531

29452 a

Endothelial PAS domain protein 1

1369703_at

5.615

1

64032 a

connective tissue growth factor

1367631_at

2.58613

1.079194

84353 b

beta-catenin

1369733_at

2.459261

1.906824

Bone Remodeling

24477

integrin binding sialoprotein

1368416_at

7.7875

1

56813

parathyroid hormone receptor 1

1370259_a_at

2.66125

1.123853

59328

MAD homolog 5 (Drosophila)*

1369276_at

2.14625

1.970041

79110

matrix extracellular phosphoglycoprotein

1387330_at

3.37375

0.997506

Cluster C

Cytoskeleton & Muscle Development

24582 ac

myosin heavy chain 11

1370896_a_at

5.571237

4.653653

24851 ac

tropomyosin 1, alpha

1370288_a_at

4.89204

5.13257

25365

Actin, gamma 2

1386869_at

4.126485

5.083472

29437 ac

Actin alpha 1

1369928_at

17.85533

9.397908

64362 ac

Desmin

1367600_at

2.398671

2.356318

114489 d

dystroglycan 1

1389105_at

5.441386

7.678867

303468 bd

Sarcoglycan

1372240_at

2.9525

2.708798

25485

myosin IC

1369779_at

5.11

2.61875

81531

profilin II

1367970_at

3.62625

4.4225

24170

Adducin 1, alpha

1388487_at

2.475238

2.510223

Cell growth & Cell Cycle

24842

tumor protein p53

1367830_a_at

2.264291

2.543204

64457 d

N-myc downstream regulated 4

1370229_at

4.279081

3.103067

29576 d

WNT1 inducible signaling pathway protein 2

1369484_at

7.956218

2.918245

24183

adenylate kinase 1

1370011_at

4.118338

4.754549

25163

cyclin dependent kinase inhibitor 2A

1369194_a_at

14.86273

8.253055

50594

neuroblastoma, suppression of tumorigenicity 1

1387004_at

3.827506

2.863581

58919

cyclin D1

1371150_at

3.147613

2.447929

64363

v-raf murine sarcoma 3611 viral oncogene homolog 1

1388305_at

2.02

2.018793

83570

c-fos induced growth factor (vascular endothelial growth factor D)

1387709_at

11.6725

3.355

94201

cyclin-dependent kinase 4

1372739_at

2.388806

2.154783

Cluster D

Adipocyte Differentiation

24252

CCAAT/enhancer binding protein, alpha

1369658_at

0.460345

0.627943

25664

peroxisome proliferator activated receptor, gamma

1369179_a_at

0.291579

0.79108

Cluster F

Lipid Binding & Transport

140868

fatty acid binding protein 5

1370281_at

0.144064

0.4143

170538

protein kinase C, delta

1387114_at

0.365549

0.470085

25023

protein kinase C, beta 1

1370585_a_at

0.028032

0.061769

25056

retinol binding protein 1

1367939_at

0.468695

0.471976

25728

apolipoprotein E

1370862_at

0.308694

0.087332

25292

apolipoprotein C-I

1368587_at

0.175235

0.329354

29184

cd36 antigen

1386901_at

0.055742

0.035525

29510

phosphatidylcholine transfer protein

1387058_at

0.346607

0.226442

79124

ZAP 36/annexin IV

1389305_at

0.488443

0.480585

79451

adipocyte protein aP2

1368271_a_at

0.039507

0.01239

Catabolism & Lysosomal Enzymes

117033 ac

matrix metalloproteinase 12

1368530_at

0.02401

0.214259

171052 ac

matrix metalloproteinase 13

1388204_at

0.155018

0.195806

25335 ac

matrix metalloproteinase 7

1368766_at

0.150338

0.189753

24331 ac

elastase 1

1387819_at

0.108743

0.2376

25166 ac

caspase 1

1369186_at

0.255206

0.175345

171329 ac

ubiquitin specific protease 15

1370460_at

0.295028

0.444408

24539 ac

lipoprotein lipase

1386965_at

0.016611

0.039975

54249 bd

Adipsin

1388602_at

0.18685

0.047754

313387 bd

ubiquitin specific protease 1

1376687_at

0.417153

0.373377

24944 ac

lysosomal membrane glycoprotein 2

1370010_at

0.430907

0.347294

Ras protein signal transduction

114203

adaptor protein with pleckstrin homology and src homology 2 domains

1368605_at

0.2262

0.175548

24525

Kirsten rat sarcoma viral oncogene homologue 2 (active)

1370035_at

0.312723

0.375405

24605

neuroblastoma RAS viral (v-ras) oncogene homolog

1372032_at

0.191657

0.238384

81504

growth factor receptor bound protein 2

1368386_at

0.373241

0.484997

Defense Response

113959

complement component 5, receptor 1

1368742_at

0.234295

0.239768

116591

Fc receptor, IgG, low affinity III

1367850_at

0.292948

0.310885

24223 a

beta-2 microglobulin

1371440_at

0.13671

0.16094

24494 ac

interleukin 1 beta

1398256_at

0.055097

0.172791

56822 ac

CD86 antigen

1387627_at

0.206497

0.402268

25599 ac

CD74 antigen

1367679_at

0.011698

0.040091

60350 ac

CD14 antigen

1368490_at

0.469431

0.412767

24930 a

CD8 antigen, alpha chain

1369877_at

0.36815

0.4273

24931 a

CD8 antigen, beta chain

1387739_at

0.203248

0.376336

24932 ac

CD4 antigen

1369483_at

0.204226

0.301498

  1. The fold change are of treated versus untreated cells from young (3 month) or old (15 month) rats. In genes that have multiple probe sets, a representative probe set was displayed.
  2. a) gene was selected with the relevant function in both rat genes and mouse orthologs
  3. b) gene was selected with the relevant function in mouse orthologs,
  4. c) gene was selected with the relevant function in both rat genes and human orthologs
  5. d) gene was selected with the relevant function in human orthologs,
  6. *) MAD homolog 5 appears also under the function of angiogenesis