Figure 1

Domain architectures observed in the GIY-YIG superfamily. Numbers in round brackets indicate NCBI gene identification (GI) numbers of representative members of proteins sharing domain architecture. All representatives are divided into presumably monophyletic groups according to the sequence clustering. Light yellow blocks indicate the common GIY-YIG domain. Other domain abbreviations are: ANK=ANKRD41, ankyrin repeat domain 41; LEM, nuclear membrane-associated proteins domain; His/Cys-rich, histidine- and cysteine-rich conserved region; RVT, reverse transcriptase; CCCC, region with four conserved Cys residues; UvrBb, UvrB-binding domain; EndoV, Endonuclease V-like nuclease domain; Cho-CTD, C-terminal domain found in Cho and Cho-related proteins; EXOIII, exonuclease domain in the α and ε subunits of DNA-polymerase; UNKNOWN, different conserved domains of unknown function; SOH1, component of the RNA polymerase II transcription complex in S. cerevisiae; N-MTase, predicted DNA or RNA or protein MTase acting on exocyclic amino groups in bases or amino acids.; HsdR, restriction subunit of a putative Type I RM system (the GIY-YIG domain is inserted at position ~800); Numod1-3, conserved DNA-binding domains of homing endonucleases; HTH, Helix-turn-helix; wHTH, winged-helix-turn-helix; COG3860. SF1 Helicase, putative Superfamily 1 helicase domain.