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Table 4 Phenotypic changes in mice carrying loss-of-function mutations of the predicted brain and PBMC target genes.

From: Characterization of microRNA expression profiles in normal human tissues

Phenotype

Brain

PBMC

Random

Nervous system1

21

5

5

Immune system2

2

8

7

Nervous/immune3

2

6

2

Embryonic lethal4

2

0

4

Other systems5

3

4

11

Normal6

1

7

4

Total gene number

31

30

33

  1. 1 Phenotype in nervous system, including behavioral and neurological defects, but no defects in immune and hematopoietic system.
  2. 2 Phenotype in immune system, including the hematopoietic system, but no nervous system or behavioral/neurological defects.
  3. 3 Phenotype from both 1 and 2 can be seen.
  4. 4 Embryonic lethal with no other phenotypic records, indicating that the embryo dies too early to observe meaningful phenotype.
  5. 5 Defects in other tissues/organs/systems than nervous and immune systems.
  6. 6 The phenotypic record showed no defect was seen.
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BMC Genomics

ISSN: 1471-2164

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