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Table 3 Comparative LOD scores in candidate regions using SNP-GWS and STR-GWS data

From: Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies

  

SNP-GWS

STR-GWS

CHR

Region

NPL

p value

PAR DOM

PAR REC

NPL

p value

PAR DOM

PAR REC

2

2p22.3

2.25

0.012

1.45

0.20

-0.21

0.600

0.00

0.00

3

3p21.31p14.3

1.95

0.030

0.64

0.68

1.01

0.200

0.00

0.16

4

4p14q12

2.22

0.013

1.38

1.40

1.65

0.050

1.34

1.29

7

7q21.11q21.3

2.59

0.005

1.00

2.01

1.77

0.040

0.48

0.94

11

11q13.5q14.3

2.51

0.006

1.04

0.20

0.99

0.200

0.84

0.20

14

14q21.1q21.3

2.41

0.008

1.03

0.30

0.98

0.200

0.75

0.77

  1. Comparative NPLOD scores and PLOD scores (HLOD) under dominant (PAR DOM) and recessive models (PAR REC) using SNP-GWS and STR-GWS data in candidate regions according to Smith et al [15] (NL: values < 1 in NPLOD or PLOD). Values > 1.00 are highlighted in bold.
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BMC Genomics

ISSN: 1471-2164

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